Update on capecitabine in colorectal cancer


Several controlled trials have compared capecitabine-that contains combinations with one another or with alternative regimens

involving bolus or infusional 5-FU. A listing of the randomized trials with capecitabine regimens, which is discussed

in further detail within this section, include capecitabine/oxaliplatin (CapOx) versus capecitabine/irinotecan (CapIri) TREE-1

trial CapOx versus FUFOX the ecu Organization for Research and Management of Cancer study of FOLFIRI versus XELIRI ±

cyclo-oxygenase-II inhibitor (COX II) and also the adjuvant Mayo Clinic/Roswell Park (RP) versus XELOX study.

Grothey et al. began a multicenter, randomized phase II trial of CapIri and CapOx in 161 patients utilizing a day-1 and -8

schedule every 3 days [22, 23]. Both groups received capecitabine 2,000 mg on days 1–14. Four early deaths one of the primary 40 patients within the CapIri arm

forced a serving reduction from 100 to 80 mg/m2. There wasn’t any comparable issue in the first 40 patients given oxaliplatin, and also the dose continued to be unchanged at 70

mg/m2 throughout the research. Subsequently, any patient died within two months of finding the reduced and comparatively

low dose of irinotecan, giving a 6% overall mortality for your arm from the trial. Two deaths were because of septic diarrhea and

two to lung embolism, reflecting what appears to become a general inclination to elevated thromboembolic occasions with capecitabine.

Early mortality in patients given CapOx was 1%. Diarrhea was more prevalent with CapIri compared to CapOx (grade 3–4 occasions

in 23% of patients versus. 14%). Physical neuropathy was more prevalent with CapOx (6% versus. 1%), and rates of hands-feet syndrome were

comparable (grade 2 occasions in 9% of CapIri patients and sevenPercent of CapOx patients and grade 3 in % and 1%, correspondingly). The

RR with CapOx was 55% with CapIri, 41%. Median OS within the two arms was >17 several weeks with CapOx and 18.8 several weeks with CapIri.

(Crossover was allowed in the finish from the study.)

Within the randomized phase II TREE-1 trial, 150 first-line patients were randomized to FOLFOX6 (including oxaliplatin 85 mg/m2, LV 350 mg, 5-FU bolus 400 mg/m2, and infusional 2,400 mg/m2 over 46 hrs, every 2 days), bFOL (oxaliplatin 85 mg/m2 on days 1 and 15 LV 20 mg/m2 and bolus 5-FU 500 mg/m2 on days 1, 8, and 15 every 4 days) or CapOx (oxaliplatin 130 mg/m2 first day, capecitabine 1,000 mg/m2 orally two times daily for fourteen days every 3 days) [24]. The general incidence of grade 3–4 adverse occasions was similar on FOLFOX and bFOL arms however, more grade

3 neutropenia happened around the FOLFOX arm (27.8% versus. 10.5%). There have been more patients withdrawn because of toxicities around the bFOL

in contrast to the FOLFOX arm (11.1% versus. 7.9%, p value not significant). CapOx were built with a greater incidence of grade 3–4 nonhematologic toxicities (i.e., nausea [15.6%], vomiting

[15.6%], lack of fluids [18.8%], diarrhea [21.9%], and hands-feet syndrome [15.6%]) compared to FOLFOX and bFOL arms, and much more patients

were withdrawn because of toxicities around the CapOx arm compared to other two arms (34.4%, p = .004, Fisher’s exact test). The protocol was amended to match yet another 210 patients to get bevacizumab added

to every regimen and also to lessen the CapOx dose by 15%.

Within the German AIO (Association of Medical Oncology from the German Cancer Society) trial, 476 patients were randomized to FUFOX

(5-fluorouracil 2,000 mg/m2 24-hour infusion folinic acidity 500 mg/m2 oxaliplatin 50 mg/m2 on days 1, 8, 15, and 22 every 5 days) or CapOx (capecitabine 1,000 mg/m2 two times each day on days 1–14, oxaliplatin 70 mg/m2 on days 1 and eight, every 3 days) [25]. Grade 3–4 neuropathy was more prevalent with FUFOX compared to CapOx (25% versus. 16%). This difference seemed to be observed in the randomized

phase II study. Both in the phase II and phase III studies, toxicities were comparable between your 5-FU– and capecitabine-that contains

arms. Evaluating rates of diarrhea across these studies shows that there might be some advantage inside a fractionated day-1 and

-8 schedule, as utilized by AIO.

RRs were in the plethora of 40%–50% both in arms from the AIO phase III trial and over the two arms from the TREE-1 trial. An overview

from the effectiveness data of those three randomized trials is supplied in Table 3⇓ [23–25]. Additionally, the Spanish TTD Group has proven identical produces a randomized phase II study [26]. The big phase III trial from Roche has very lately issued an announcement proclaiming that there’s been no difference

in progression-free survival between FOLFOX and XELOX, with leads to be presented in the European Society of Medical Oncology

(ESMO) 2006 meeting.

Resourse: http://theoncologist.alphamedpress.org/content/11/9/

Colon cancer stage IV, Blog #9. Xeloda horrific side effects.