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James M H
December 12, 2016 1:04 am
We highly recommend the discovering that ibuprofen reduces the chance of cancer of the lung dying is a result of reductions in dehydroepiandrosterone (DHEA) brought on by ibuprofen.
"Maximum amounts of DHEA although not cortisol or ACTH were blunted by ibuprofen, suggesting another regulating these synthetic pathways within the adrenal cortex inner zone during acute inflammation." (Crit Care Mediterranean. 2000 Jun28(6):2103-6).
It is indeed my hypothesis that evolution selected dehydroepiandrosterone (DHEA) since it optimizes replication and transcription of DNA, that’s, genes. Therefore, DHEA levels affect all tissues and all sorts of tissues compete for available DHEA, particularly the brain. (I believe transformative choice of DHEA created mammalia. "Hormones in Mammalian Evolution," Rivista di Biologia / Biology Forum 2001 94: 177-184). DHEA naturally starts to decline round the day of twenty to twenty-five, reaching really low levels in senior years. When DHEA is low or decreasing, all tissues are adversely affected. I would recommend DHEA could be the natural ligand of cannabinoid receptors. Disruption of / low DHEA may trigger oncogene initiation, but cancer, as all tissues, depends upon DHEA for growth once began.
Accordingly, ibuprofen ought to be found to both increase cancer formation in addition to reduce cancer growth. The literature supports this conundrum. My explanation of the also explains the bond of ibuprofen with cancer of the lung dying reductions.
Therefore, since ibuprofen reduces DHEA, ibuprofen should reduce development of cancer of the lung by reduction of DHEA.
December 13, 2016 11:12 am
What’s the peak manufacture of DHEA? What’s the rate of decline of DHEA as we grow older?