Variations between colorectal cancer and cancer of the colon


  • Surgery – Surgery for cancer of the colon might be suggested at any stage of disease, while surgery alone without chemotherapy or radiotherapy is usually prescribed for stages 1 and a pair of. By comparison, surgery for rectal cancer can be carried out from stages one to three, frequently along with chemotherapy and radiotherapy.
  • Impossibility of Surgery – Surgery for cancer of the colon is really a much easier when compared with rectal cancer. With rectal surgery, it’s harder to gain access to the tumor and also to avoid most of the structures surrounding it.
  • Colostomy – Those who have gone through rectal cancer surgery possess a greater probability of a lasting colostomy. It is because removing the rectal sphincter if frequently needed, which could neither get replaced nor reconstructed.
  • Radiotherapy – Radiation isn’t generally employed for cancer of the colon but is perfect for rectal cancer (predominately stage two or three).
  • Chemotherapy – Chemotherapy for cancer of the colon is frequently utilized as an adjunct to surgery in phases 3 and 4 (and often 2). With rectal cancer, chemotherapy can be utilized despite stage 1 disease.
  • Postoperative complications – Individuals with rectal cancer are more inclined to have publish-surgical complications in comparison with individuals with cancer of the colon surgery, who’re more vulnerable to short-term medical complications.

Cancer Of The Colon Research

There also seem like fairly huge difference between cancers that originate around the right side from the colon (climbing colon) and individuals that arise around the left (climbing down colon, sigmoid colon, rectum).

We know the tissues from the right side have different cells than individuals from the left, a vestige of embryonic development. Data has since proven that survival rates for left-sided cancers are usually much better than individuals from the right. While these bits of information are thought significant, it’s not yet been determined whether this can alter treatment approaches.

As our knowledge of genetics improves, we’re also starting to find variations within the common gene mutations and molecular grounds for these cancers. By better understanding these variations, scientists aspire to find immunologic and biogenetic methods to particularly target these unique cells, permitting control – as well as eradication – from the disease.


Hong, T. Clark, J. and K. Haigis. "Cancers from the Colon and Rectum: Identical or Fraternal Twins?" Cancer Discovery. 2012. 2(2):117-21.

Lee, Y. Lee, Y. Chuang, J. and Lee, J. "Variations in Survival Between Colon and Rectal Cancer from SEER Data." PLoS One. November 12, 2013 8(11): e78709.

van der Slip, M. Bastiaannet, E. Mesker, W. et al. "Variations Between Colon and Rectal Cancer in Complications, Short-Term Survival and Recurrences.: Worldwide Journal of Colorectal Disease. 2016 31(10):1683-1691.

Venook, A. Niedzwiecki, D. Innocenti, F. et al. "Impact of Primary (1º) Tumor Location on Overall Survival (OS) and Progression-Free Survival (PFS) in Patients (pts) with Metastatic Colorectal Cancer (mCRC): Analysis of CALGB/SWOG 80405 (Alliance)." 2016 ASCO Annual Meeting, Chicago, IL. June 2-6, 2016 abstract 3504.


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