Does cancer of the colon ever metastasize to bone first? a temporal analysis of colorectal cancer progression


It’s also likely the greater sensitivity and specificity of PET and CT for discovering early metastasis in liver and lung in contrast to traditional radiography may take into account the strong correlation among lesions towards the liver, lung, and bone within our study. Possibly, concurrent participation of other organs were available but went undetected within the patients who’d only bone lesions within the Kanthan et al study [8]. However, confirming if the complete lack of true isolated bone metastasis is sign of colorectal cancer will need a bigger study population.

This research searched for to recognize whether disease progression towards the lung area could predict metastasis to bone. Although lung lesions have particular interest like a forerunner of future bone metastasis as evidenced through the small amount of time span from lung metastasis to bone participation, the lesions in bone always appear after metastasis to liver, lung, or (inside a large percentage) both. Because the average 5-year rate of survival of cancer of the colon patients with metastasis to bone remains 8.1% [9], and typically, 67% of individuals who developed bone participation in this survey were dead 16 several weeks after recognition of bone metastasis, the significance of recognizing disease progression and potential value of bone metastasis can’t be overemphasized.

Disease Progression

The findings within this the research into cancer of the colon metastasis towards the bone and lung area correlate with results in the present literature. Our findings of lung metastasis in 25% of patients and bone metastasis in five.5% of patients concur using the is a result of other studies [2, 8]. As reported within the literature that colorectal cancer metastasizes first towards the liver or lung area, which both contain dense capillary beds that may trap tumor cells and seed them in to these organs [3]. The atmosphere of the specific organ and it is affect on tumor cell adhesion may also lead towards the effectiveness of tumor spread, which happens in colorectal cancer patients most often within the liver and lung area [2, 3].

However, the 30% incidence of liver metastasis within our study is a lot less than the incidence of liver metastasis in earlier studies, which reported liver participation in 70–83% of patients [2, 8]. The low incidence of liver lesions detected within this study are closely related to patient selection, because clinicians had resected the main tumors in many in our patients and were monitoring these to evaluate possible recurrence throughout the analysis. Throughout the study period, 44% of individuals who developed liver metastasis continued to be free from other organ metastasis, and 84% had liver lesions that never progressed to bone.

The proportion of metastatic lung participation within our study correlates with this reported within the literature. However, unlike individuals with liver lesions, 78% of individuals with lung lesions demonstrated concurrent disease participation in other organs. When combined with temporal distinction between time from liver metastasis to bone metastasis and also the time from lung metastasis to bone metastasis, this finding shows that lung metastasis signifies refractory, costly disease more precisely than liver metastasis does. Most lung and liver metastases that people observed contained multiple lesions. However, solitary lesion happened more frequently within the liver than that within the lung.

Even though this study attempted to locate the relationship between your pattern of disease progression and the introduction of bone metastasis, the resulting subpopulation of patients with metastasis to bone was small, and many had diffuse participation of multiple organs simultaneously point. Thus, further studies having a bigger patient population with increased frequent imaging studies are required to determine if the order of organ participation has any effect on the introduction of bone metastasis.

Lymphatic spread and native recurrence were excluded from analysis within this study since most patients had gone through local resection with local lymph node dissection before their staging work-up. Further analysis from the possible relationship between your nodal spread of disease, including local or distant nodal metastasis and metastasis to bone inside a different patient population setting, could be interesting. After cancer cells break with the defense barrier from the the lymphatic system, especially individuals lymph nodes outdoors the portal system, cancer may metastasize more readily towards the lung area and bone. We didn’t evaluate brain metastasis due to the low sensitivity of PET for brain tumor recognition and our PET/CT imaging protocol doesn’t range from the brain.


A strength of the study is it incorporated an organized method of evaluate disease progression. While using files of three nuclear medicine radiologists facilitated the development of a sizable database that spanned institutions, widened census, and maintained quality and consistency within the imaging reports.

Additionally, unlike most studies which have characterised colorectal cancer metastasis, we used PET and CT, that are newer and much more sensitive tools to identify cancer of the colon metastasis, instead of less precise methods like traditional radiography or bone scintigraphy [8]. Our answers are therefore an immediate reflection of the items diagnosticians can anticipate seeing when staging a colorectal cancer patient using current technology.


A significant limitation of the study may be the retrospective nature. We acquired the imaging studies during staging and subsequent follow-up using a mixture of PET with correlation of the recent CT and PET/CT. Additionally, the imaging modality each and every time point varied among patients so we only adopted the patients throughout the imaging periods due to the retrospective nature from the study.

The majority of the patients from the 3 major outlying medical facilities experienced surgical resection from the primary tumor together with elimination of neighboring lymph nodes before they’d an in depth staging work-up. This patient population therefore might not be associated with general colorectal patients.


Colorectal Cancer w/ Lung Metastases Stage IV