Important Safety Details About KEYTRUDA® (pembrolizumab)
KEYTRUDA is really a medicine that could treat certain cancers with your defense mechanisms. KEYTRUDA may cause your defense mechanisms to fight normal organs and tissues in lots of areas of the body and may affect how they work. These complaints can occasionally become serious or existence-threatening and can result in dying.
Call or visit your physician immediately should you develop any signs and symptoms from the following problems or these signs and symptoms worsen:
Lung problems (pneumonitis). Signs and symptoms of pneumonitis can include difficulty breathing, chest discomfort, or new or worse cough.
Intestinal problems (colitis) that can result in tears or holes inside your intestine. Signs and signs and symptoms of colitis can include diarrhea or even more bowel motions than normal stools which are black, tarry, sticky, and have bloodstream or mucus or severe stomach-area (abdomen) discomfort or tenderness.
Liver problems (hepatitis). Signs and signs and symptoms of hepatitis can include yellowing of the epidermis or even the whites of the eyes, queasiness, discomfort around the right side of the abdomen (abdomen), dark urine, feeling less hungry than normal, or bleeding or bruising easier than usual.
Hormone gland problems (particularly the thyroid, pituitary, adrenals, and pancreas). Signs and signs and symptoms that the hormone glands aren’t working correctly can include rapid heartbeat, weight reduction or putting on weight, elevated sweating, feeling more hungry or thirsty, urinating more frequently than normal, hair thinning, feeling cold, constipation, your voice will get much deeper, muscle aches, dizziness or fainting, or headaches that won’t disappear or unusual headache.
Kidney problems, including nephritis and kidney failure. Indications of kidney problems can include alternation in the quantity or colour of your urine.
Problems in other organs. Indications of these complaints can include rash, alterations in eyesight, severe or persistent muscle or joint problems, severe muscle weakness, low red bloodstream cells (anemia), difficulty breathing, irregular heartbeat, feeling tired, or chest discomfort (myocarditis).
Infusion (IV) reactions that can often be severe and existence-threatening. Signs and signs and symptoms of infusion reactions can include chills or trembling, difficulty breathing or wheezing, itching or rash, flushing, dizziness, fever, or feeling like fainting.
Getting treatment immediately might help keep these complaints from increasingly serious. Your physician will check you of these problems during treatment with KEYTRUDA. Your physician may treat you with corticosteroid or hormone substitute medicines. Your physician may should also delay or completely stop treatment with KEYTRUDA for those who have severe negative effects.
Before you decide to receive KEYTRUDA, inform your physician should you have defense mechanisms problems for example Crohn’s disease, ulcerative colitis, or lupus have experienced a body organ transplant have lung or difficulty in breathing have liver problems and have every other medical conditions.
If you’re pregnant or intend to conceive, inform your physician. KEYTRUDA may damage your developing fetus. Females who is able to conceive should make use of an effective approach to contraception during treatment and not less than 4 several weeks following the final dose of KEYTRUDA. Inform your physician immediately should you conceive during treatment with KEYTRUDA.
If you’re breastfeeding or intend to breastfeed, inform your physician. It’s not known if KEYTRUDA passes to your breast milk. Don’t breastfeed during treatment with KEYTRUDA as well as for 4 several weeks after one last dose of KEYTRUDA.
Inform your physician about all of the medicines you are taking, including prescription and also over-the-counter medicines, vitamins, and herbal medicines.
Common negative effects of KEYTRUDA include feeling tired, itching, diarrhea, decreased appetite, rash, fever, cough, difficulty breathing, discomfort in muscles, bones or joints, constipation, and nausea.
These aren’t all of the possible negative effects of KEYTRUDA. Inform your physician for those who have any side-effect that bothers you or that doesn’t disappear. To learn more, ask your physician or pharmacist.
You ought to report gloomy results of prescription medications towards the Food and drug administration.
Visit www.food and drug administration.gov/medwatch or call 1‑800‑FDA‑1088.
Please browse the associated Medication Guide for KEYTRUDA and talk to your physician. The doctor Prescribing Information is also available.